Germ Cell Tumor (GCT), Dysgerminoma, Metastatic Ovarian Cancer.
Malignant germ cell tumors (GCT) of the ovary account for 2-3% of all ovarian neoplasms and occur mostly in the second and third decade of life. Over the past three decades, survival rates for germ cell tumors have dramatically improved, coincident with more aggressive surgical staging and combination chemotherapy. Although there are several studies describing ovarian GCT and fertility.
Malignant Ovarian Germ Cell Tumors. Ovarian germ cell malignant tumors are uncommon, and account for approximately 5 percent of ovarian cancer cases. They can occur in women of any age, but are more often found in young women or adolescent girls. These tumors frequently affect only one ovary and are generally curable if found and treated early.
Nonseminomatous germ cell tumors are cancer and are found in the brain. Yolk sac tumors, (also called endodermal sinus tumors) are usually cancer. They form in the testicles and ovaries.
In general, ovarian germ cell tumors develop when the DNA in the cells in the ovary changes or mutates. Then the cells start to grow and divide at a faster rate than cells in normal tissue. Some of the genes involved are proto-oncogenes, which normally control cell growth and division. Mutated proto-oncogenes are called oncogenes. KIT is one such proto-oncogene that when mutated allows for.
Management of Ovarian Germ Cell Tumors David M. Gershenson ABSTRACT Purpose To review contemporary management of malignant ovarian germ cell tumors (MOGCT). Design The literature on the topic of MOGCT is reviewed, including pathology, prognostic factors, surgical strategies, postoperative therapy, late effects of therapy, and treatment of recurrence. Results Prognostic factors for MOGCT.
After ovarian germ cell tumor has been diagnosed, tests are done to find out if cancer cells have spread within the ovary or to other parts of the body. The process used to find out whether cancer has spread within the ovary or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. Unless a doctor is sure the cancer.
Germ Cell Tumors of the Ovary An Update Francisco F. Nogales, MD, PhD; Isabel Dulcey, MD; Ovidiu Preda, MD, PhD Context.—The field of ovarian germ cell tumors (OGCTs) has remained relatively unchanged in the last 2 decades. However, the introduction of new stem cell pluripotency markers has provided a new understanding into the identification and taxonomy of OGCT types. New data have.